Aggressive cancer in liver, Neuroendocrine cancer spread to liver and bones
While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease.
Preventing Liver Cancer
To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, aggressive cancer in liver different scenarios may occur.
The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases.
Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process.
The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation pre-existing and tumor-inducedhost innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge.
These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. Cellular and molecular aspects of the liver architecture and function. The tumor microenvironment at different stage of hepatic metastasis.
Role of CXC chemokines and receptors in liver metastasis — impact on liver resection-induced engraftment and tumor growth. Aggressive cancer in liver of Inflammation in the early stages of liver metastasis.
Aggressive cancer in liver
Signal transduction in tumor-endothelial cell communication. Tumor dormancy in liver metastasis: clinical and experimental evidence and implications for treatment.
Metastatic cancer in liver treatment Surgical Treatment of Colorectal Cancer Metastasis to the Liver quando vaccinarsi contro papilloma virus Aggressive variants of prostate cancer - Are we ready to apply specific treatment right now?
Role of the IGF- axis in liver metastasis: experimental and clinical evidence. Breast Cancer Liver Metastasis.
Aggressive variants of prostate cancer - Are we ready to apply specific treatment right now? Cancer Treat Rev.
Imaging of Hepatic Metastases. Proteomic profiling of hepatic metastases: Paving the way to individualized therapy.
Targeting Angiogenesis in the Treatment of Hepatic Metastasis. Uveal melanoma — a paradigm of aggressive cancer in liver liver metastasis.
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