Papilloma infection, Te-ar mai putea interesa şi …
HPV is causing cât să bea pastile pentru viermi variety of benign, borderline and malignant disorders, with common anogenital signs.
The association of various types of treatment is still the preferred method to papilloma infection HPV infection. This paper offers information about possible systemic treatments of HPV infection, based on the documentation from the PubMed databaseincluding immunomodulatory drugs, antiviral papilloma infection, therapeutic HPV vaccines and biological therapy.
Keywords HPV, HPV systemic treatment, therapeutic vaccines, systemic immunomodulators, papilloma infection antiviral drugs Rezumat Infecţia umană cu diferite genotipuri ale virusului papiloma uman HPV este una dintre cele mai frecvente infecţii virale cu transmitere sexuală. HPV provoacă o varietate de afecţiuni benigne, precanceroase şi maligne, cu semne anogenitale comune. HPV necesită tratament sistemic antiviral, dar în prezent nu există un medicament antiviral papilloma infection aprobat împotriva infecţiilor cu HPV.
Asocierea diferitelor tipuri de tratament este încă metoda preferată pentru eradicarea infecţiei cu HPV. Această lucrare oferă detalii despre posibilele tratamente sistemice ale infecţiei cu HPV, pe baza documentaţiei din baza de date PubMedinclusiv medicamente imunomodulatoare, medicamente antivirale, vaccinuri HPV terapeutice şi terapie biologică.
Aproapefemei dezvoltă cancerul de col uterin șidecedează din cauza acestuia în fiecare an.
Cuvinte cheie HPV papilloma infection sistemic HPV vaccinuri terapeutice imunomodulatoare sistemice medicamente antivirale sistemice Genital infections with human papillomaviruses HPVamong the most common sexually transmitted diseases STDgenerate alarming signals in human health, due to the prevalence and dissemination, as well as to various pathologies induced mostly at the level of the genital tract 1.
The virus has tropism for feminine genital tract.
INFECŢIA GENITALĂ ŞI PERIGENITALĂ CU PAPILOMA VIRUSUL UMAN (HPV) LA COPILUL MIC.
Discussion At this moment, there is no routine effective therapy to treat lesions induced by HPV. HPVshr infection with various clinical forms at various levels requires an early diagnosis and proper treatment 5.
The treatment improves symptoms, especially regarding evolutive flares, lowering the possibility of infection by HPV and possibly through other possible STD associated 6. It is recommended that all clinical and subclinical papilloma infection lesions at the level of epithelium and mucous membranes be tested for HPV 7.
The possibility of identifying the genotype is useful, especially papilloma infection infections with HPVshr, when the therapy must be prompt and targeted, and post-therapeutic follow-up must be done for long term in order to prevent the neoplastic transformation 8.
Conform datelor experimentale şi epidemiologice se pare că HPV reprezintă un important factor de risc pentru dezvoltarea cancerului la om, ocupând locul al doilea după fumat. Astfel, cea mai frecventă cauză de mortalitate asociată infecţiei HPV este cancerul cervical, iar în ultimii ani s-a înregistrat un progres remarcabil în ceea ce priveşte înţelegerea istoriei naturale a infecţiei la femei2. Infecţia HPV prezintă importanţă şi pentru bărbaţi, atât datorită faptului că aceştia papilloma infection un rezervor al virusului cât şi prin patologia benignă şi malignă asociată cu HPV la sexul masculin1;2.
Taking into account the fact that many lesions with confirmed HPV etiology have a self-limiting evolution, it is recommended that before papilloma infection the treatment the patient papilloma infection be kept under observation for several weeks, expecting the spontaneous healing 9.
A multidisciplinary approach is required for optimal decision making, treatment planning, and post-treatment response assessment. The therapy of the infections produced by HPV is local and systemic.
Topical treatment removes lesions, but the absence of infection is not guaranteed The absence of a sterilizing therapy diminishes papilloma infection effectiveness of evaluation and monitorization of the sexual partners, but their testing can identify ignored lesions HPV is ubiquitous, especially in the lower genital tract, which makes the pharmacological treatment to be considered as the therapy of choice The treatment papilloma infection interferon and immunomodulating agents inosine did not bring the presumed results many side effects which limited the therapeutic doses Figure 1.
There is No Shame in HPV Infection
Antiviral polyamide in HPV infection 18 Systemic antiviral treatment would be the treatment of choice, but at present there is no systemic antiviral drug approved for HPV This article details the progresses in the treatment of systemic infection with HPV, regardless of type, location and genotype Table 1.
HPV vaccines currently licensed in the United States of America 21 This paper provides papilloma infection scientific data on the possible systemic treatments of human infections with HPV confirmed etiology.
Recurrences occur after papilloma infection therapies. All topical treatments are associated with local skin reactions including itching, burning, erosions and pain.
A number of studies highlighted papilloma infection role of HPV systemic treatment, from which the most prevalent are aromatic retinoids, interferon, inosine, while other studies have reported benefits papilloma infection using hydroxicloroquine Antiviral medications like foscarnet, cidofovir and ribavirin were used as systemic HPV treatment with good results Figure 2.
HPV by the numbers 30 A history of genital warts, a positive Papilloma infection test result, or abnormal cervical, vaginal, vulvar or anal cytology, all indicate a prior HPV infection, but not necessarily with the HPV types included in the vaccines.
The vaccination is still recommended in individuals within the recommended age range who have evidence of prior HPV infection, as it can still provide protection against infection with HPV vaccine types not already acquired.
Cervical cancer is the second type of women cancers, most cases being reported in the developing countries, where it represents the main cause for mortality in women. The cases of cancer were histologically confirmed and staged after FIGO. Moldavia — Related to the cytological diagnosis, HPV was detected in
However, these patients should be advised that vaccination will have no therapeutic effect on preexisting HPV infection or in HPV-associated diseases, and the potential benefit of HPV vaccination is not as great as if they were vaccinated before their sexual debut 24, The therapeutic anti-HPV vaccines are supposed to induce cell-mediated immunity and to papilloma infection the development of benign and malignant lesions induced by this virus.
Cell-mediated rather than humoral immune responses are important for the clearance of established infections.
The HPV E6 and E7 oncoproteins are essential for the onset and maintenance of malignancy; thus, they are unlikely to escape immune responses by mutation. They are also expressed papilloma infection and at high levels, and therefore represent near-ideal targets for the development of therapeutic vaccines against established HPV infections and lesions.
Other proteins useful for targeting of early viral infections are E1 viral helicase and E2, which are expressed at higher levels papilloma infection E6 and E7 at very early stages before viral genome integration.
An ideal therapeutic vaccine would target these proteins to induce strong tumor-specific T-cell type 1 and papilloma infection lymphocyte CTL responses able to kill infected papilloma infection malignant cells The types of therapeutic vaccines, which are developed and evaluated at the moment, are vaccines with viral or bacterial vectors, vaccines based on dendritic cells and modified tumor cells, vaccines based on peptides, proteins or RNA replicons or DNA vaccines 27, Progress will likely come from clinical trials testing the treatment of low-grade lesions of the cervix, with the aim of accelerated and sustained resolution following either HPV immune response, or drug treatments as the stepping stone for wider therapeutic application The treatment is reserved for patients with visible warts.
The general treatment strategy is to eliminate as many of the visible lesions as possible until the host immune system can control the viral replication The treatment is papilloma infection infection recommended for subclinical anogenital or mucosal human papillomavirus infection in the absence of coexistent dysplasia Recent research directions are promising to provide antiviral medications anti-HPV with the characteristics aforementioned 36,
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