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Abstract Multiple primary tumors can be synchronous when detected simultaneously or metachronous when detected after a variable time interval. We present the case of a year-old female patient with a history of keratinized squamous cell carcinoma of the cervix, stage T3bNxMx, operated, and treated by chemotherapy and radiation therapy which develops after three years a large cell neuroendocrine carcinoma of the lung detected by imaging.

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Of major importance in the selection of the optimal neuroendocrine cancer large cell approach was the accurate determination of the histological type of the metachronous tumor by microscopy and immunohistochemical techniques. The discrete respiratory symptoms and the absence of lung imaging screening accounted for tumor development to an inoperable stage, thus emphasizing the importance of close monitoring of the oncologic patient, thus neuroendocrine cancer large cell increasing their chances of survival.

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Metachronous cancer. R Neuroendocrine cancer large cell Med J ; 96 4 : Metachronous lung cancer that presented as bilateral synchronous lung cancer.

Tumorile pulmonare neuroendocrine TNE Tumorile pulmonare neuroendocrine cancer large cell TNE Tumorile pulmonare neuroendocrine cuprind un spectru larg de boli.

J Thorac Dis ; 5 3 : E Second primary lung cancer. Ann Thorac Surg ; 59 4 : The management of second primary lung cancers.

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A single centre experience in 15 years. Eur J Cardiothorac Surg ; 21 3 : Characteristics and outcome of patients with second primary lung cancer.

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Metachronous double primary cancer after diagnosis of gastric cancer. Cancer Res Treat ; 44 3 : Squamous cell carcinoma antigen, tumor-associated trypsin inhibitor, and carcinoembryonic antigen for monitoring cervical cancer.

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Am J Clin Oncol ; Johansson L. Histopathologic classification of lung cancer: Relevance of cytokeratin and TTF-1 immunophenotyping.

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Ann Diagn Pathol ; 8 5 : Fisseler-Eckhoff A, Demes M. Neuroendocrine tumors of the lung.

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Cancers ; 4: