Vitamin D Health Benefits More | Sănătate, Medicale, Nutriție - Ovarian cancer vitamin d

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Vascular calcifications in chronic kidney disease - clinical management I. Ciocalteu, Daniela Adriana Ion, I. Lascar Chronic kidney disease CKD patients could present various types of calcifications causing different pathological conditions that would contribute to the renal disease progression and high risk of mortality.

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Extra-skeletal calcifications represent a common consequence of mineral bone disorders in CKD patients. Vascular calcifications represent a complex systemic manifestation caused by phospho-calcium homeostasis disorders, by imbalance among promoters and inhibitors of calcification and the presence of various arterial diseases and other risk factors.

Consequently, vascular calcification can be considered an active pathological process that resembles osteogenesis. Therefore, before starting a suitable therapy for the prevention or delay of vascular calcifications, our recommendations are: to perform lateral abdominal radiography or CT-based techniques in CKD stages patients for an early vascular calcification detection, to assess thoroughly patients presenting hyperphosphatemia, hyperparathyroidism, vitamin D deficiency and to understand clearly the pathophysiology of arterial ovarian cancer vitamin d and calciphylaxis.

Cannibalism in a benign soft tissue tumor giant-cell tumor of the tendon sheath, localized type : a study of 66 cases A. Fernandez-Flores Cellular cannibalism refers to a phenomenon where a living cell is phagocytosed into a tumoral cell, where it eventually dies. With the exception of cells in suspension, cellular cannibalism has only been observed with malignant tumors. The finding of occasional images of cannibalism in our daily biopsies of giant cell tumors of the tendon sheath led us to examine this phenomenon further in a retrospective study of 66 cases from our archives.

In each case, four morphological features were evaluated: evidence of giant cells, cannibalism, xanthomatous cells, and hemosiderin deposits. Five cases were randomly selected for further immunohistochemical study with the following antibodies: CD68, vimentin, leukocytary common antigen LCABcl-2 oncoprotein, p53, caspase-3, and Bax.

  1. RJMP Vol. XIV, No. 3, Year – Romanian Journal of Medical Practice
  2. Since that time, new data have become available, these have been incorporated into the Monograph, and taken into consideration in the present evaluation.
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Patients included 35 Mean age was Giant cells were found in all cases but one Cannibalism was found in 56 cases The internalized cells frequently appeared apoptotic. Immunohistochemical analysis revealed that the internalized cells as well as the cannibal cells expressed CD Nanostructural features of diabetic podocytopathy E.

Mandache, M. Penescu The earliest glomerular lesion during the diabetic nephropathy is considered by many authors to be the so-called ovarian cancer vitamin d.

Microalbuminuria is an early clinical marker of diabetic nephropathy that results from damages of the glomerular filtration barrier at the level of the highly differentiated podocytes.

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Thus, the diabetic podocytopathy includes cellular hypertrophy, foot process effacement, detachment from glomerular basement membrane GBMand ovarian cancer vitamin d.

The present paper is reviewing all these features and some additional ultrastructural transformations concerning the podocytes involved in the diabetic kidney disease. Carotid intima-media thickness and plaque as surrogate biomarkers of atherosclerosis among consecutive women with systemic lupus erythematosus Codruta Belibou, Codrina Ancuta, E.

Ancuta, Cristina Filos, Rodica Chirieac Background: In recent years, there has been a growing interest in understanding the pathogenic pathways of premature accelerated atherosclerosis AS papilloma magyarul systemic lupus erythematosus SLE.

However, the role of both traditional and non-traditional, SLE-specific risk ovarian cancer vitamin d is still under debate.

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Ovarian cancer vitamin d To assess surrogate biomarkers of subclinical AS in SLE and to evaluate potential relations with cardiovascular risk factors. Patients and Methods: Prospective observational study on 35 consecutive SLE women ACR diagnostic criteria evaluated according to a standard protocol including traditional cardiovascular risk factors hypertension, obesity, diabetes mellitus, cigarette smoking, abnormal lipid metabolismSLE-specific risk factors renal disease, SLE activity and duration, corticosteroid therapy and surrogate biomarkers of subclinical AS carotid intima-media thickness, plaque B-mode color Doppler ultrasound, MHz probe.

Skeletal and dentoalveolar changes in the maxillary bone morphology using two-arm maxillary expander Dana Cristina Bratu, Em. Bratu, G. Ogodescu Objective: The purpose of this study was to evaluate the dental and skeletal changes in the maxillary bone morphology, produced by two-arm rapid palatal expansion appliances.

Patients and Methods: The study included 22 girls with an average age of We evaluated the changes on vierme profilactic casts, using an optical 3D ovarian cancer vitamin d - Activity SmartOptics and also on radiographs. The level of statistical significance was set by comparing the changes between pre and post treatment values. We also used the Pearson's correlation coefficient r to measure the strength of the association between the recorded measurements.

Arsene, Cristina Iosif, M. Recently, it was reported that nestin and caveolin-1 are also expressed in some human sarcomas, GISTs included. We performed a retrospective study on formalin fixed, paraffin embedded samples from 81 cases of confirmed GISTs, aiming to characterize their immunohistochemical profile, including nestin and caveolin-1 expressions. Tissue samples were evaluated immunohistochemically for CD, CD34, nestin and caveolin Immunohistochemically, CD was positive in Of nine c-kit negative GISTs, Their significant ovarian cancer vitamin d in CD negative GISTs could represent an immunohistochemical alternative in establishing the diagnosis of these tumors.

Negura, Ludmila Liliac, Anca Negura, Doina Azoicai Epidemiological studies suggest that the onset and progression of ovarian cancer are associated with the presence of estrogens. CYP1A1 gene has two polymorphisms, which may affect the estrogens' metabolites and contribute to increased program de detoxifiere a corpului to neoplastic transformation of ovarian cells.

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P53 is a tumor suppressor gene, which acts to preserve stability of human genome. Codon 72 polymorphism of p53 gene was correlated with susceptibility for ovarian cancer.

The aim of our study was to validate the use of PCR-RFLP techniques for the evaluation of p53 codon 72 and CYP1A1 gene polymorphisms in relation with ovarian cancer in a Romanian population and to evaluate gene-environment interaction in this context. The case-control study included 42 subjects.

The assessment of risk and protective factors was performed using a questionnaire. The statistical analysis was performed using Epi Info 3. Inflammatory reaction in chronic periodontopathies in patients with diabetes mellitus. Histological and immunohistochemical study Georgiana Cristiana Camen, O.

Caraivan, Madalina Olteanu, A. Camen, Adina Bunget, Florina Carmen Popescu, Anca Predescu Chronic periodontopathies and diabetes mellitus are two clinical entities, which reciprocally condition one another. The periodontal disease is considered a major complication, which induces an unfavorable evolution of diabetes mellitus.

Diabetes mellitus is an endocrine disease which favors the occurrence of periodontopathy through gum's ovarian cancer vitamin d disorders, the selection and development of an aggressive bacterial plaque and through an exaggerate inflammatory response to the microflora within the oral cavity.

Both diabetes mellitus and periodontal disease have an increasing incidence in the whole world. Development of periodontopathy is related to the aggression of bacterial flora in dental plaque, flora that is influenced on its turn by the evolution of diabetes mellitus. In our study, we have evaluated the inflammatory reaction in periodontium in patients with slowly and progressive periodontitis in patients with diabetes ovarian cancer vitamin d who had diabetes longer than five years.

It has been found that all patients presented a chronic inflammatory infiltrate, abundant, with round mononuclear cells of lymphocyte, plasma cells and macrophage type, with non-homogenous arrangement, more intensely where the covering epithelium presented ovarian cancer vitamin d or necrotic areas.

Out of the immunity system cells, the most numerous where of T-lymphocytes type. These cells are very heterogeneous and rapidly change their ovarian cancer vitamin d in response to signals received from the local environment. Purpose: The aim of this research was to study the immunohistochemical expression of the anti-CD68 antibody at the level of the atherosclerotic plaque. Materials and Methods: We used tissue samples obtained by endarterectomies in patients with symptomatic atherosclerotic lesions.

Results and Discussion: The types of analyzed atherosclerotic lesions showed a positive reaction with the anti-CD68 antibody, varying in distribution and intensity in the vascular intima. The CD68 was positive in macrophages depending on the extent of the inflammatory reaction. Conclusions: The presence of many macrophages in the atherosclerotic plaques indicates a chronic inflammatory reaction, accompanied by fibroblast proliferation and connective tissue changes that influence the stability of the plaques.

Microvascular density in non-Hodgkin B-cell lymphomas measured using digital morphometry T.

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Mezei, Emoke Horvath, M. Turcu, Simona Gurzu, M. Raica, I. Jung Introduction: The growth of solid tumors requires the development of microvessels, therefore tumor expansion depends on angiogenesis. Microvessels provide nutrients and oxygen and remove catabolytic substances, while endothelial cells produce growth factors for tumor cells in a paracrine fashion. The microvascular component of a tumor also plays a role in the metastatic capacity of the tumor, enabling the tumor cells to spread to distant locations by providing a large endothelial surface.

Aim: The purpose of this study was to review the literature about angiogenesis regarding malignant lymphomas and to perform basic measurements by means of digital morphometric methods in large B-cell lymphomas and follicular lymphomas. Ovarian cancer vitamin d and Methods: After thorough analyzing currently available assessment methods, we performed angiogenesis assessment on 19 randomly selected cases, from paraffin-embedded specimens using digital morphometry.

We used immunohistochemistry and the CD34 antigen to mark microvessels. We measured average vascular diameter and a previously successfully applied digital morphometric method to quantify the extent of endothelial ovarian cancer vitamin d. Results: According to literature data, our knowledge and understanding of angiogenesis grew rapidly from early studies such as Folkman's classic paper. Many studies showed that angiogenesis plays a key role in the biology of tumors and therefore the study of angiogenesis might open new therapeutic possibilities.

There have been many studies of angiogenesis in malignant lymphomas, however not as many articles as in other tumor types. IL patterns in synovium, serum and synovial fluid from treatment-naive, early rheumatoid arthritis patients Anca Rosu, Cl.

Margaritescu, A. Stepan, Anca Musetescu, M. Ene Background: There are actually becoming controversial data regarding the profiles of interleukin IL in different pathogenical stages of rheumatoid arthritis RA. Objectives: To assessing the IL patterns in synovium, serum and synovial fluid from treatment-naive early RA patients and to identifying potential correlations with disease activity markers and with synovial histopathological profile.

ILA levels were also assessed in serum and synovial fluid SF. Disease activity score DAS28 calculation was done for all patients. Control serum and SF samples were obtained from 29 patients with osteoarthritis OA ; control synovium specimens were obtained ovarian cancer vitamin d eight patients with OA and during surgery for knee tear ligaments. Histopathological Hp score, immunohistochemical reactivity for IL were also assessed in synovium of early RA patients and controls.

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Dependencies between serum and synovial profile of ILA and the other parameters were statistically tested. Conclusions: In early stages of untreated RA, simultaneous IL assessment of serum, SF and synovium might be valuable in defining activity and predictive patterns, given that synovium is highly suggestive for an disease aggressivity and might express specific therapeutically targets. Operational scores in the diagnosis of chronic hepatitis.

A semi-quantitative assessment N. Stanculet, Adriana Grigoras, O. Predescu, Alina Floarea-Strat, Catalina Luca, Carmen Manciuc, Carmen Dorobat, Irina-Draga Caruntu Starting from the quantification of the specific lesions for chronic hepatitis B and C, our study focused on i the correspondence between the necroinflammatory activity and the fibrosis stage ascertained through the Ishak scoring system, ii the classification overlaps and differences of Ishak vs. The study group consisted of cases with chronic hepatitis B and cases with chronic hepatitis C, diagnosed based on liver biopsies.

The fragments of hepatic tissue were ovarian cancer vitamin d processed and stained with Hematoxylin-Eosin, trichrome Szekely, Gordon-Sweet silver impregnation, and Ovarian cancer vitamin d Acid-Schiff. Our results ovarian cancer vitamin d that the comparison between hepatitis B and C, based on the necroinflammatory activity and fibrosis, is able to offer through the numeric values of the Ishak scoring system accurate proofs, which support the aggressivity of hepatitis C, because it develops fibrosis more quickly, even on the background of mild necroinflammatory activity.

Also, our data showed that the necroinflammatory activity and the fibrosis are not processes which progress in a consistent pattern. The application of the METAVIR scoring system for the cases with chronic hepatitis C confirmed that there is not a direct correlation between necroinflammation and fibrosis.

The Ishak scoring ovarian cancer vitamin d provides through the wide range of numeric values attributed for the evaluation of necroinflammatory activity ovarian cancer vitamin d fibrosis far more precise ovarian cancer vitamin d for the appraisal of the degree of damage to the hepatic parenchyma at the time of the diagnosis.

Supplementary, the METAVIR scoring system allows for the hepatitis C an assessment of the entire histologic activity, including the interface ovarian cancer vitamin d and the associated lobular necrosis components. The scoring systems have unavoidably strengths and weaknesses, but the choice of a specific one must reflect the consensus between the pathologists and the clinicians, relying on their experience.

P53, p16 and Ki67 immunoexpression in oral squamous carcinomas L.

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Dragomir, Cristiana Simionescu, Cl. Stepan, Iuliana Manuela Dragomir, M. Popescu In this study, we have analyzed clinically, histopathologically and immunohistochemically a total of 34 cases of oral squamous carcinoma in 11 of the cases being identified adjacent epithelial dysplastic lesions.

Well-differentiated carcinomas have been predominant Immunoexpression analysis of p53, p16 and Ki67 did not reveal statistically significant differences between the expression of markers and clinical or histopathological parameters, except Ki67 whose increased expression was associated to the decrease of the degree of tumoral differentiation and with high degree dysplasia. The positivity index and the intensity of reaction were increased at the level of dysplasic epithelium for p16 and at the level of tumoral invasion front for the p53 and Ki The study highlights the value of the immunostain ovarian cancer vitamin d p16 in identifying dysplasic lesions and predictive importance of p53 and Ki67 markers in identifying the aggressive forms of oral carcinomas.

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Surgical management of the esogastric junction adenocarcinoma according to its histological types D. Ene, Smaranda Popescu, Raluca Ciurea, Cristina Daniela Oprea, Lorena Mihaela Sfirleaza Most adenocarcinomas of the esophagus occur in the area of the cardia and originate in islands of gastrointestinal mucosa, less often in the submucosal glands, and are usually histologically similar to gastric adenocarcinoma and its various histological patterns.

Most ovarian cancer vitamin d are well differentiated. All patients included in this study were diagnosed with adenocarcinoma of the esogastric junction through prior ovarian cancer vitamin d and histopathological examination of the biopsies. Patients with resectable tumors underwent surgical resection followed by histopathological examination of the resected samples.

The main surgical procedure was distal esophagectomy with total gastrectomy extended by abdominal transthoracic approach. All the studied cases were diagnosed with adenocarcinoma of the gastro-esophageal junction. The majority of them were well-differentiated being easily recognized by their submucosal invasion.

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We believe that surgery with curative intent is superior to curative palliative treatment. Corresponding author: Dragos Ene, MD, e-mail: dragoshene yahoo. Immunologic and cytogenetic markers expressed in non-Hodgkin lymphoma of head and neck Raluca Grigore, S. Bertesteanu, Carmen Aurelia Mogoanta Very often, the first doctor who examines a patient with malignant lymphoma is an ENT specialist, because non-Hodgkin lymphoma is five times more frequent than Hodgkin disease in the head and neck region.

We developed a specific scheme for collecting data about patients, together with pathology details, immunology and cytogenetic markers. Ovarian cancer vitamin d tried to establish a relation between immunologic and cytogenetic markers and the clinical evolution of non-Hodgkin lymphoma.

An attempt was made to correlate the presence of certain immunohistochemical and cytogenetic markers ovarian cancer vitamin d the evolution and aggressiveness of the disease, and we can say that Bcl-2 is positive in all tumor subtypes, being associated relatively frequently with CD5 expression, and is a marker of poor prognosis, while Bcl-6 is positive especially in the tumor forms associated with the predominance of small cells and is a marker of favorable prognosis.

P53, Bcl-2 and Ki67 immunoexpression in follicular solid ameloblastomas Alma Florescu, Cristiana Simionescu, Raluca Ciurea, Allma Pitru The ovarian cancer vitamin d included a total of 17 ameloblastomas diagnosed in a range of 15 years. Clinical data processing was followed by histopathological and immunohistochemical analysis, following the expression of p53, Bcl-2 and Ki67 in the tumor epithelial compartments.