Colorectal cancer therapy, colorectal cancer - Traducere în română - exemple în engleză | Reverso Context
Delivering cancer treatment on a nanodisc helps eliminate tumors
Credit: Dr. Rui Kuai and Dr.
What Are The Treatments for Colorectal Cancer
Wenmin Yuan In the wrestling match with cancer, chemoimmunotherapy is the new strong arm, and it is building muscle with a nanodisc disguised as "good cholesterol. The nanodisc is made of a synthetic version of high density lipoprotein HDLalso known as " good cholesterol. Moon, Ph.
In colorectal cancer therapy mouse tumor models of colon cancer, researchers found up to 85 percent of the tumors were completely eliminated when combining the nanodisc-delivered chemotherapy with immune checkpoint blockers, a common immunotherapy treatment. In a more challenging model of colorectal cancer therapy, one that metastasized to the liver, colorectal cancer therapy treatment also showed an excellent response rate of 88 percent.
To determine if cells are harmful to the body and need to be attacked, the immune system uses certain molecules called checkpoints.
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But some cancer cells avoid an immune system attack by producing proteins that trick the checkpoints. Checkpoint blockers were colorectal cancer therapy to allow immune cells to kill cancer cells.
These immunotherapy treatments are highly successful in some patients, but only about 20 percent will benefit. By using the synthetic HDL, which mimics natural HDL in the body, the researchers were able to hide the chemotherapy from the immune system.
James Moon, Ph. Credit: University of Michigan College of Pharmacy "When we attached the chemotherapy drug to the synthetic HDL, we saw significant improved circulation half-life, improved delivery to the tumor cells and a better accumulation of the drug in the tumor cells," colorectal cancer therapy study co-senior author Anna Schwendeman, Ph.
The immune system was empowered to recognize and attack tumor cells.
Colorectal cancer treatment options, Traducere "metastatic colorectal" în română
There were no overt colorectal cancer therapy effects to the new delivery system. And interestingly, the researchers discovered another unexpected benefit: less impact on the heart.
But we found that by delivering doxorubicin on the synthetic HDL nanodisc, we saw better accumulation diferiți viermi și cum să le tratați the drug in the tumor and we didn't detect any cardiotoxicity," Schwendeman says.
That may have contributed to the absence of cardiotoxicity," she adds, noting that more research is needed to confirm that speculation.
The link between increased fiber consumption and a decreased risk of colorectal cancer is still uncertain.
Our results demonstrating their efficacy in multiple tumor models suggest that our strategy may have wide applications in multiple cancer types," Moon says. Phase I clinical trials have been conducted for the synthetic HDL nanodisc, which has been determined to be safe, Moon says.
Next, the researchers are working to test the therapy on humans in clinical trials. Explore further More information: "Elimination of established tumors with nanodisc-based combination chemoimmunotherapy" Science Advances DOI: Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission.
- Student Project abstract The investigation of platinum-based drug effect on tumor stem cells responsible for tumor generation and propagation is a novel and expanding field, and in the colorectal cancer casuistry they are many features uncovered.
- Acest obiectiv îndrăzneţ al proiectului va fi realizat prin achiziţionarea de aparatură medical, activităţi de formare a personalului medical implicat în diagnosticarea şi managementul acestor patologii în cadrul unor workshopuri şi sesiuni de training, dar şi prin acţiuni de informare a populaţiei asupra necesităţii screeningului pentru prevenirea şi diagnosticul precoce al cancerelor de colon şi respective de col uterin, prin materiale de promovare, forumuri de conştientizare pentru publicul larg privind stilul de viaţă sănătos şi riscul de apariţie al acestor tipuei de patologii.
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